周厚庆等: Raf-1激酶与肿瘤治疗1167

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localization, phosphorylation of BAD, and Bcl-2 association. J Biol Chem 2005; 280(26): 24698-705.20 Hindley A, Kolch W. Raf-1 and B-Raf promote protein kinase C

theta interaction with BAD. Cell Signal 2007; 19(3): 547-55.21 Le Mellay V, Troppmair J, Benz R, Rapp U. Negative regulation

of mitochondrial VDAC channels by C-Raf kinase. BMC Cell Biol 2002; 3: 14.22 Kim SY, Park SG, Jung H, Chi SW, Yu DY, Lee SC, et al. RKIP

downregulation induces the HBx-mediated Raf-1 mitochondrial translocation. J Microbiol Biotechnol 2011; 21(5): 525-8.23 Hsu YL, Chen CY, Lin IP, Tsai EM, Kuo PM, Hou MF.

4-Shogaol, an active constituent of dietary ginger, inhibits me-tastasis of MDA-MB-231 human breast adenocarcinoma cells by decreasing the repression of NF-kappaB/Snail on RKIP. J Agric Food Chem 2012; 60(3): 852-61.24 Piazzolla D, Meissl K, Kucerova L, Cristina R, Manuela B. Raf-1 sets the threshold of Fas sensitivity by modulating Rok-alpha

signaling. J Cell Biol 2005; 171(6): 1013-22.25 Ehrenreiter K, Piazzolla D, Velamoor V, Sobczak I, Small JV,

Takeda J, et al. Raf-1 regulates Rho signaling and cell migration. J Cell Biol 2005; 168(6): 955-64.26 Rubiolo C, Piazzolla D, Meissl K, Beug H, Huber JC, Kolbus A,

et al. A balance between Raf-1 and Fas expression sets the pace of erythroid differentiation. Blood 2006; 108(1): 152-9.27 Tobiume K, Matsuzawa A, Takahashi T, Nishitoh H, Morita K,

Takeda K, et al. ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep 2001; 2(3): 222-8.28 Yamaguchi O, Watanabe T, Nishida K, Kashiwase K, Higuchi Y,

Takeda T, et al. Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis. J Clin Invest 2004; 114(7): 937-43.

29 O’Neill E, Rushworth L, Baccarini M, Kolch W. Role of the

kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1. Science 2004; 306(5705): 2267-70.30 Niault T, Sobczak I, Meissl K, Weitsman G, Piazzolla D, Mau-rer G, et al. From autoinhibition to inhibition in trans: the Raf-1

regulatory domain inhibits Rok-alpha kinase activity. J Cell Biol 2009; 187(3): 335-42.31 Ehrenreiter K, Kern F, Velamoor V, Meissl K, Gergana GK,

Sibilia M, et al. Raf-1 addiction in Ras-induced skin carcinogen-esis. Cancer Cell 2009; 16(2): 149-60.32 Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;

100(1): 57-70.33 Wang X, Thomson SR, Starkey JD, Page JL, Ealy AD, Johnson

SE. Transforming growth factor {beta}1 is upregulated by ac-tivated Raf in skeletal myoblasts but does not contribute to the differentiation-defective phenotype. J Biol Chem 2004; 279(4): 2528-34. 34 Riesco-Eizaguirre G, Rodríguez I, de la Vieja A, Costamagna E,

Carrasco N, Nistal M, et al. The BRAFV600E oncogene induces transforming 400 growth factor beta secretion leading to sodium iodide symporter repression and increased malignancy in thyroid cancer. Cancer Res 2009; 69(21): 8317-25.35 Samuel DS, Ewton DZ, Coolican SA, Petley TD, McWade FJ,

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