华　中　科　技　大　学　博　士　学　位　论　文

result in imbalance of levels of serum endostatin and VEGF leading to tumorigenesis. The ratio of endostatin to VEGF can be considered as an early diagnostic markers of lung cancer in smokers. Periodic determination of levels of serum VEGF and endostatin as well as the ratio of endostatin to VEGF is of clinical importance.

【Key words】Lung neoplasma; Vascular endothelial growth factor; Endostatin; Smoking

9