人参皂苷_Rh2抗肿瘤机理的研究进展(4)

第9期 郭志廷等:人参皂苷-Rh2抗肿瘤机理的研究进展

CancerRes,1998,89(7):733-740.

745

viaactivationofcaspase-1and-3andup-regulationofBaxinhumanneuroblastoma[J].ArchPharmRes,2004,27(8):834-839.

[5] FeiXF,WangBX,TashiroS,etal.Apoptotic

effectsofginsenosideRh2onhumanmalignantmela-nomaA375-S2cells[J].ActaPharmacolSin,2002,23(4):315-322.

[6] KimYS,JinSH,LeeYH,etal.GinsenosideRh2

inducesapoptosisindependentlyofBc-l2,Bc-lxL,orBaxinC6Bu-1cells[J].ArchPharmRes,1999,22(5):448-453.

[7] JinYH,YooKJ,LeeYH,etal.Caspase3-media-tedcleavageofp21WAF1/CIP1associatedwiththecyclinA-cyclin-dependentkinase-complexisaprerequisiteforapoptosisinSK-HEP-1cells[J].JBiolChem,2000,39:30256-30263.

[8] KimHE,OhJH,LeeSK,etal.GinsenosideRH-2

inducesapoptoticcelldeathinratC6gliomaviaareac-tiveoxygen-andcaspase-dependentbutBc-lX(L)-independentpathway[J].LifeSci,1999,65(3):33-40.

[9] CreiderCW.Telomeraseactivity,cellproliferation

andcancer[J].ProcNatlAcadSciUSA,1998,95:90-92.

[10] ZengXL,TuZG.Invitroinductionofdifferentia-tionbyginsenosideRh2inSMMC-7721hepatocarc-inomacellline[J].PharmacolToxico,2003,93(6):275-283.

[11] 曾小莉,涂植光.端粒酶在人参皂甙Rh2诱导肝癌细

胞分化中的作用[J].癌症,2004,23(12):1655-1659.

ZengXL,TuZG.Effectoftelomeraseonginse-nosideRh2-induceddifferentiationofhepatocarcinomacelllineSMMC-7721[J].ChineseJournalofCancer,2004,23(12):1655-1659.(inChinese)

[12] HamYM,ChoiJS,ChunKH,etal.Thec-JunN-terminalkinase1activityisdifferentiallyregulatedbyspecificmechanismsduringapoptosis[J].JBiolChem,2003,50:50330-50337.

[13] HamYM,ChunKH,ChoiJS,etal.SEK1-dependentJNK1activationprolongscellsurvivalduringG-Rh2-inducedapoptosis[J].BiochemBio-physResCommun,2003,304(2):358-364.

[14] OhM,ChoiYH,ChoiS,etal.Ant-iproliferating

effectsofginsenosideRh2onMCF-7humanbreastcancercells[J].IntJOncol,1999,14(5):869-875.

[15] NakataH,KikuchiY,TodeT,etal.Inhibitory

effectsofginsenosideRh2ontumorgrowthinnudemicebearinghumanovariancancercells[J].JpnJ

[16] Hyun-EuiK,OhJH,LeeSK,etal.Ginsenoside

Rh2inducesapoptoticcelldeathinratC6gliomaviareactiveoxygen2andcaspase-dependentbutBc-lXLindependentpathway[J].LifeSci,1999,65:33-40.

[17] KimYS,KimDS,KimSI.GinsenosideRh2and

Rh3inducedifferentiationofHL-60cellsintogranu-locytes:modulationofproteinkinaseCisoformsduringdifferentiationbyginsenosideRh2[J].IntJBiochemCellBiol,1998,30(3):327-338.

[18] 曾小莉,涂植光.人参皂甙Rh2对人肝癌细胞

SMMC-7721的诱导分化作用[J].癌症,2004,23(8):879-884.

ZengXL,TuZG.InductionofdifferentiationbyginsenosideRh2inhepatocarcinomacellSMMC-7721[J].ChineseJournalofCancer,2004,23(8):879-884.(inChinese)

[19] 周桂华,孟艳,李扬,等.人参单体皂甙Rh2对体外培

养的前列腺癌细胞株PC-3M抑制效应的研究[J].白求恩医科大学学报,2001,27(6):595-597.

ZhouGH,MengY,LiY,etal.ProhibitiveeffectofprostatecancercellPC-3MbyginsenosideRh2invitro[J].JournalofNormanBethuneUniversityofMedicineSciences,2001,27(6):595-597.Chinese)

[20] HasegawaH,SungJH,MatsumiyaS,etal.Rever-salofdaunomycinandvinblastineresistanceinmult-idrug-resistantP388leukemiainvitrothroughen-hancedcytotoxicitybytriterpenoids[J].PlantaMed,1995,61(5):409-413.

[21] JiaWW,BuX,PhilipsD.Rh2,acompoundextrac-tedfromginseng,hypersensitizesmultidrug-resistanttumorcellstochemotherapy[J].CanJPhysiolPhar-macol,2004,82(7):431-437.

[22] YunYS,LeeYS,JoSK.Inhibitionofautochtho-noustumorbyethanolinsolublefractionfromPanaxginsengasanimmunomodulator[J].PlantaMed,1993,59:521-524.

[23] ZhuJH,TakeshitaT,KitagawaI.Suppressionof

theformationofsisterchromatidexchangesbylowconcentrationsofginsenosideRh2inhumanbloodlymphocytes[J].CancerRes,1995,55:1221-1223.

[24] 葛迎春,李晨燕,任慧君,等.人参皂甙Rh2注射液对

荷肝癌(H22)小鼠免疫功能的影响[J].特产研究,2002,(3):4-7.

GeYC,LiCY,RenHJ,etal.Effectofimmunefunctioninlotushepatoma(H22)byginsenosideRh2liquid[J].SpecialWildEconomicAnimalandPlantResearch,2002(3):4-7.(inChinese)

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