The type I interferon system in the etiopathogenesis of auto(8)

18.Fitzgerald-BocarslyP,DaiJ,SinghS.Plasmacytoiddendritic

cellsandtypeIIFN:50yearsofconvergenthistory.CytokineGrowthFactorRev.2008;19:3–19.

19.BarberGN.InnateimmuneDNAsensingpathways:STING,

AIMIIandtheregulationofinterferonproductionandin ammatoryresponses.CurrOpinImmunol.2011;23:10–20.

20.PlataniasLC.Mechanismsoftype-I-andtype-II-interferon-mediatedsignalling.NatRevImmunol.2005;5:375–86.21.SamuelCE.Antiviralactionsofinterferons.ClinMicrobiol

Rev.2001;14:778–809.

22.BennettL,PaluckaAK,ArceE,CantrellV,BorvakJ,

BanchereauJ,etal.Interferonandgranulopoiesissignaturesinsystemiclupuserythematosusblood.JExpMed.2003;197:711–23.

23.BaechlerEC,BatliwallaFM,KarypisG,GaffneyPM,

OrtmannWA,EspeKJ,etal.Interferon-induciblegeneexpressionsignatureinperipheralbloodcellsofpatientswithseverelupus.ProcNatlAcadSciUSA.2003;100:2610–5.

24.StrandbergL,AmbrosiA,EspinosaA,OttossonL,

ElorantaML,ZhouW,etal.Interferon-ainducesup-regulationandnucleartranslocationoftheRo52autoantigenasdetectedbyapanelofnovelRo52-speci cmonoclonalantibodies.JClinImmunol.2008;28:220–31.

25.Stahl-HallengrenC,JonsenA,NivedO,SturfeltG.

IncidencestudiesofsystemiclupuserythematosusinSouth-ernSweden:increasingage,decreasingfrequencyofrenal.

y

lmanifestationsandgoodprognosis.JRheumatol.2000;27:no 685–91.

esu26.RahmanA,IsenbergDA.Systemiclupuserythematosus.N

l anEnglJMed.2008;358:929–39.

os27.HooksJJ,MoutsopoulosHM,GeisSA,StahlNI,DeckerJL,

repNotkinsAL.Immuneinterferoninthecirculationofpatients rFowithautoimmunedisease.NEnglJMed.1979;301:5–8.28.YtterbergSR,SchnitzerTJ.Seruminterferonlevelsinpatients

withsystemiclupuserythematosus.ArthritisRheum.1982;25:401–6.

29.BengtssonA,SturfeltG,TruedssonL,BlombergJ,AlmG,

VallinH,etal.ActivationoftypeIinterferonsysteminsystemiclupuserythematosuscorrelateswithdiseaseactivitybutnotantiretroviralantibodies.Lupus.2000;9:664–71.30.PrebleOT,RothkoK,KlippelJH,FriedmanRM,

JohnstonMI.Interferon-induced2¢-5¢adenylatesynthetaseinvivoandinterferonproductioninvitrobylymphocytesfromsystemiclupuserythematosuspatientswithandwithoutcirculatinginterferon.JExpMed.1983;157:2140–6.

31.vonWussowP,JakschiesD,HochkeppelH,HorisbergerM,

HartungK,DeicherH.MXhomologousproteininmono-nuclearcellsfrompatientswithsystemiclupuserythematosus.ArthritisRheum.1989;32:914–8.

32.CrowMK,WohlgemuthJ.Microarrayanalysisofgeneexpres-sioninlupus.ArthritisResTher.2003;5:279–87.

33.HanGM,ChenSL,ShenN,YeS,BaoCD,GuYY.Analysis

ofgeneexpressionpro lesinhumansystemiclupuserythe-matosususingoligonucleotidemicroarray.GenesImmun.2003;4:177–86.

34.HjelmervikTO,PetersenK,JonassenI,JonssonR,

BolstadAI.Geneexpressionpro lingofminorsalivaryglandsclearlydistinguishesprimarySjogren’ssyndromepatientsfromhealthycontrolsubjects.ArthritisRheum.2005;52:1534–44.

35.BaechlerEC,BatliwallaFM,ReedAM,PetersonEJ,

GaffneyPM,MoserKL,etal.Geneexpressionpro linginhumanautoimmunity.ImmunolRev.2006;210:120–37.

ThetypeIinterferoninautoimmunediseases

235

36.HiggsBW,LiuZ,WhiteB,ZhuW,WhiteWI,

MorehouseC,etal.Patientswithsystemiclupuserythema-tosus,myositis,rheumatoidarthritisandsclerodermashareactivationofacommontypeIinterferonpathway.AnnRheumDis.2011Jul28(Epubaheadofprint).

37.CederbladB,BlombergS,VallinH,PerersA,AlmGV,

RönnblomL.Patientswithsystemiclupuserythematosushavereducednumbersofcirculatingnaturalinterferon-a-producingcells.JAutoimmun.1998;11:465–70.

38.BlombergS,ElorantaM-L,MagnussonM,AlmGV,

RönnblomL.ExpressionofthemarkersBDCA-2and-4andproductionofinterferon-abyplasmacytoiddendriticcellsinsystemiclupuserythematosus.ArthritisRheum.2003;48:2524–32.

39.BlombergS,ElorantaM-L,CederbladB,NordlindK,

AlmGV,RönnblomL.Presenceofcutaneousinterferon-aproducingcellsinpatientswithsystemiclupuserythematosus.Lupus.2001;10:484–90.

40.FarkasL,BeiskeK,Lund-JohansenF,BrandtzaegP,

JahnsenFL.Plasmacytoiddendriticcells(naturalinter-feron-a/b-producingcells)accumulateincutaneouslupuserythematosuslesions.AmJPathol.2001;159:237–43.

41.RönnblomL,AlmGV.Thenaturalinterferon-aproducing

cellsinsystemiclupuserythematosus.HumImmunol.2002;63:1181–93.

42.TucciM,QuatraroC,LombardiL,PellegrinoC,

DammaccoF,SilvestrisF.Glomerularaccumulationofplas-macytoiddendriticcellsinactivelupusnephritis:roleofinterleukin-18.ArthritisRheum.2008;58:251–62.

43.BåveU,NordmarkG,LövgrenT,RönnelidJ,CajanderS,

ElorantaML,etal.ActivationofthetypeIinterferonsysteminprimarySjögren’ssyndrome:apossibleetiopathogenicmech-anism.ArthritisRheum.2005;52:1185–95.

44.ElorantaML,BarbassoSH,Ul$K,RönnblomL,AlmGV,

LundbergIE.Apossiblemechanismforendogenousactiva-tionofthetypeIinterferonsysteminmyositispatientswithanti-Jo-1oranti-Ro52/Ro60autoantibodies.ArthritisRheum.2007;56:3112–24.

45.VallinH,BlombergS,AlmGV,CederbladB,RönnblomL.

Patientswithsystemiclupuserythematosus(SLE)haveacirculatinginducerofinterferon-alpha(IFN-a)productionactingonleucocytesresemblingimmaturedendriticcells.ClinExpImmunol.1999;115:196–202.

46.VallinH,PerersA,AlmGV,RönnblomL.Anti-double-strandedDNAantibodiesandimmunostimulatoryplasmidDNAincombinationmimictheendogenousIFN-ainducerinsystemiclupuserythematosus.JImmunol.1999;163:6306–13.

47.BåveU,MagnussonM,ElorantaM-L,PerersA,AlmGV,

RönnblomL.FcgRIIaisexpressedonnaturalIFN-aproducingcells(plasmacytoiddendriticcells)andisrequiredfortheIFN-aproductioninducedbyapoptoticcellscombinedwithlupusIgG.JImmunol.2003;171:3296–302.

48.RönnblomL,ElorantaML,AlmGV.ThetypeIinterferon

systeminsystemiclupuserythematosus.ArthritisRheum.2006;54:408–20.

49.LövgrenT,ElorantaML,BåveU,AlmGV,RönnblomL.

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