Heterogeneity of Monoclonal Antibodies(16)

发布时间:2021-06-07

92.Wallick SC,Kabat EA,Morrison SL.1988.Glyco-

sylation of a VH residue of a monoclonal antibody against alpha(1—6)dextran increases its affinity for antigen.J Exp Med168:1099–1109.

93.Rothman RJ,Warren L,Vliegenthart JF,Hard

KJ.1989.Clonal analysis of the glycosylation of immunoglobulin G secreted by murine hybrido-mas.Biochemistry28:1377–1384.

94.Malan Borel I,Gentile T,Angelucci J,Margni RA,

Binaghi RA.1990.Asymmetric Fab glycosylation in guinea-pig IgG1and Ig G2.Immunology70: 281–283.

95.Bond A,Cooke A,Hay FC.1990.Glycosylation of

IgG,immune complexes and IgG subclasses in the MRL-lpr/lpr mouse model of rheumatoid arthritis.

Eur J Immunol20:2229–2233.

96.Wright A,Tao MH,Kabat EA,Morrison SL.1991.

Antibody variable region glycosylation:Position effects on antigen binding and carbohydrate struc-ture.EMBO J10:2717–2723.

97.Coco-Martin JM,Brunink F,van der Velden-de

Groot TA,Beuvery EC.1992.Analysis of glyco-forms present in two mouse IgG2a monoclonal antibody preparations.J Immunol Methods155: 241–248.

98.Couto JR,Padlan EA,Blank EW,Peterson JA,

Ceriani RL.1994.Humanization of KC4G3,an anti-human carcinoma antibody.Hybridoma13: 215–219.

99.Leung SO,Dion AS,Pellegrini MC,Losman MJ,

Grebenau RC,Goldenberg DM,Hansen HJ.1995.

Effect of VK framework-1glycosylation on the binding affinity of lymphoma-specific murine and chimeric LL2antibodies and its potential use as a novel conjugation site.Int J Cancer60: 534–538.

100.Leung SO,Goldenberg DM,Dion AS,Pellegrini MC,Shevitz J,Shih LB,Hansen HJ.1995.Con-struction and characterization of a humanized, internalizing,B-cell(CD22)-specific,leukemia/ lymphoma antibody,LL2.Mol Immunol32: 1413–1427.

101.Mechref Y,Muzikar J,Novotny MV.2005.

Comprehensive assessment of N-glycans derived from a murine monoclonal antibody:A case for multimethodological approach.Electrophor-esis26:2034–2046.

102.Huang L,Biolsi S,Bales KR,Kuchibhotla U.2006.

Impact of variable domain glycosylation on anti-body clearance:An LC/MS characterization.Anal Biochem349:197–207.(Epub2005Nov2028.) 103.Endo T,Wright A,Morrison SL,Kobata A.1995.

Glycosylation of the variable region of immunoglo-bulin G—site specific maturation of the sugar chains.Mol Immunol32:931–940.

104.Coloma MJ,Trinh RK,Martinez AR,Morrison SL.

1999.Position effects of variable region carbohy-drate on the affinity and in vivo behavior of an

anti-(1!6)dextran antibody.J Immunol162: 2162–2170.

105.Parham P.1983.On the fragmentation of mono-clonal IgG1,IgG2a,and IgG2b from BALB/c mice.

J Immunol131:2895–2902.

106.Burton DR.1985.Immunoglobulin G:Functional sites.Mol Immunol22:161–206.

107.Kim H,Yamaguchi Y,Masuda K,Matsunaga C, Yamamoto K,Irimura T,Takahashi N,Kato K, Arata Y.1994.O-glycosylation in hinge region of mouse immunoglobulin G2b.J Biol Chem269: 12345–12350.

108.Hagmann ML,Kionka C,Schreiner M,Schwer C.

1998.Characterization of the F(ab’)2fragment of a murine monoclonal antibody using capillary iso-electric focusing and electrospray ionization mass spectrometry.J Chromatogr A816:49–58.

109.Hirayama K,Yuji R,Yamada N,Kato K,Arata Y, Shimada plete and rapid peptide and glycopeptide mapping of mouse monoclonal anti-body by LC/MS/MS using ion trap mass spectro-metry.Anal Chem70:2718–2725.

110.Jiskoot W,van de Werken G,Martin JM,Green BN,Beuvery EC,Crommelin DJ.1992.Applica-tion of electrospray mass spectrometry(ES-MS) for the analysis of monoclonal antibody Fc sub-units.Pharm Res9:945–951.

111.Kamoda S,Ishikawa R,Kakehi K.2006.Capillary electrophoresis with laser-inducedfluorescence detection for detailed studies on N-linked oligo-saccharide profile of therapeutic recombinant monoclonal antibodies.J Chromatogr A1133: 332–339.(Epub2006Sep2001.)

112.Santora LC,Krull IS,Grant K.2002.Determina-tion of recombinant monoclonal antibodies and noncovalent antigen TNF-a trimer using Q-TOF mass spectrometry.Spectroscopy17:50–57. 113.Lewis DA,Guzzetta AW,Hancock WS,Costello M.

1994.Characterization of humanized anti-TAC, an antibody directed against the interleukin2 receptor,using electrospray ionization mass spec-trometry by direct infusion,LC/MS,and MS/MS.

Anal Chem66:585–595.

114.Roberts GD,Johnson WP,Burman S,Anumula KR,Carr SA.1995.An integrated strategy for structural characterization of the protein and car-bohydrate components of monoclonal antibodies: Application to anti-respiratory syncytial virus MAb.Anal Chem67:3613–3625.

115.Ashton DS,Beddell CR,Cooper DJ,Craig SJ, Lines AC,Oliver RW,Smith MA.1995.Mass spectrometry of the humanized monoclonal anti-body CAMPATH1H.Anal Chem67:835–842. 116.Lines AC.1996.High-performance liquid chro-matographic mapping of the oligosaccharides released from the humanised immunoglobulin, CAMPATH1H.J Pharm Biomed Anal14:601–608.

DOI10.1002/jps JOURNAL OF PHARMACEUTICAL SCIENCES,VOL.97,NO.7,JULY2008

HETEROGENEITY OF MONOCLONAL ANTIBODIES2441

Heterogeneity of Monoclonal Antibodies(16).doc 将本文的Word文档下载到电脑

精彩图片

热门精选

大家正在看

× 游客快捷下载通道(下载后可以自由复制和排版)

限时特价:7 元/份 原价:20元

支付方式:

开通VIP包月会员 特价:29元/月

注:下载文档有可能“只有目录或者内容不全”等情况,请下载之前注意辨别,如果您已付费且无法下载或内容有问题,请联系我们协助你处理。
微信:fanwen365 QQ:370150219