Heterogeneity of Monoclonal Antibodies(15)

发布时间:2021-06-07

amino acid substitution abolishes the heterogene-ity of chimeric mouse/human(IgG4)antibody.Mol Immunol30:105–108.

66.Brody T.1997.Multistep denaturation and hier-

archy of disulfide bond cleavage of a monoclonal antibody.Anal Biochem247:247–256.

67.Schuurman J,Perdok GJ,Gorter AD,Aalberse

RC.2001.The inter-heavy chain disulfide bonds of IgG4are in equilibrium with intra-chain dis-ulfide bonds.Mol Immunol38:1–8.

68.Hunt G,Nashabeh W.1999.Capillary electrophor-

esis sodium dodecyl sulfate nongel sieving analysis of a therapeutic recombinant monoclonal anti-body:A biotechnology perspective.Anal Chem 71:2390–2397.

69.Schauenstein E,Schauenstein K,Dachs F,Reiter

M,Leitsberger A,Weblacher M,Maninger K, Horejsi H,Steinschifter W,Hirschmann C,Felsner P.1996.Reactive disulfide bonds in immunoglo-bulin G.A unique feature in serum proteins of dif-ferent species.Biochem Mol Biol Int40:433–446.

70.Zhang W,Czupryn MJ.2002.Free sulfhydryl in

recombinant monoclonal antibodies.Biotechnol Prog18:509–513.

71.Taylor FR,Prentice HL,Garber EA,Fajardo HA,

Vasilyeva E,Blake Pepinsky R.2006.Suppression of sodium dodecyl sulfate-polyacrylamide gel elec-trophoresis sample preparation artifacts for ana-lysis of IgG4half-antibody.Anal Biochem 353:204–208.(Epub2006Mar2009.)

72.Chaderjian WB,Chin ET,Harris RJ,Etcheverry

TM.2005.Effect of copper sulfate on performance of a serum-free CHO cell culture process and the level of free thiol in the recombinant antibody expressed.Biotechnol Prog21:550–553.

73.Sears DW,Mohrer J,Beychok S.1977.Relative

susceptibilities of the interchain disulfides of an immunoglobulin G molecule to reduction by dithio-threitol.Biochemistry16:2031–2035.

74.Virella G,Parkhouse RM.1973.Sensitivity to

reduction of human immunoglobulin G of different heavy chain sub-classes.Immunochemistry10: 213–217.

75.Nashef AS,Osuga DT,Lee HS,Ahmed AI,Whi-

taker JR,Feeney RE.1977.Effects of alkali on proteins.Disulfides and their products.J Agric Food Chem25:245–251.

76.Florence TM.1980.Degradation of protein disul-

phide bonds in dilute alkali.Biochem J189:507–520.

77.Galande AK,Trent JO,Spatola AF.2003.Under-

standing base-assisted desulfurization using a variety of disulfide-bridged peptides.Biopolymers 71:534–551.

78.Vasilyeva E,Woodard J,Taylor FR,Kretschmer

M,Fajardo H,Lyubarskaya Y,Kobayashi K,Ding-ley A,Mhatre R.2004.Development of a chip-based capillary gel electrophoresis method for

quantification of a half-antibody in immunoglobu-lin G4samples.Electrophoresis25:3890–3896. 79.Forrer K,Hammer S,Helk B.2004.Chip-based gel

electrophoresis method for the quantification of half-antibody species in IgG4and their by-and degradation products.Anal Biochem334:81–88.

80.Abel CA,Spiegelberg HL,Grey HM.1968.The

carbohydrate contents of fragments and polypep-tide chains of human gamma-G-myeloma proteins of different heavy-chain subclasses.Biochemistry 7:1271–1278.

81.Mizuochi T,Taniguchi T,Shimizu A,Kobata A.

1982.Structural and numerical variations of the carbohydrate moiety of immunoglobulin G.

J Immunol129:2016–2020.

82.Parekh RB,Dwek RA,Sutton BJ,Fernandes

DL,Leung A,Stanworth D,Rademacher TW, Mizuochi T,Taniguchi T,Matsuta K,Takeuchi F,Nasano Y,Miyamoto T,Kobata A.1985.Asso-ciation of rheumatoid arthritis and primary osteoarthritis with changes in the glycosylation pattern of total serum IgG.Nature316:452–457.

83.Taniguchi T,Mizuochi T,Beale M,Dwek RA,

Rademacher TW,Kobata A.1985.Structures of the sugar chains of rabbit immunoglobulin G: Occurrence of asparagine-linked sugar chains in Fab fragment.Biochemistry24:5551–5557.

84.Mizuochi T,Hamako J,Titani K.1987.Structures

of the sugar chains of mouse immunoglobulin G.

Arch Biochem Biophys257:387–394.

85.Jefferis R.2005.Glycosylation of recombinant

antibody therapeutics.Biotechnol Prog21:11–

16.

86.Co MS,Scheinberg DA,Avdalovic NM,McGraw K,

Vasquez M,Caron PC,Queen C.1993.Genetically engineered deglycosylation of the variable domain increases the affinity of an anti-CD33monoclonal antibody.Mol Immunol30:1361–1367.

87.Leibiger H,Wustner D,Stigler RD,Marx U.1999.

Variable domain-linked oligosaccharides of a human monoclonal IgG:Structure and influence on antigen binding.Biochem J338:529–538. 88.Fanger MW,Smyth DG.1972.The oligosaccharide

units of rabbit immunoglobulin G.Multiple carbo-hydrate attachment sites.Biochem J127:757–765.

89.Fanger MW,Smyth DG.1972.The oligosaccharide

units of rabbit immunoglobulin G.Asymmetric attachment of C2-oligosaccharide.Biochem J 127:767–774.

90.Savvidou G,Klein M,Horne C,Hofmann T,Dor-

rington KJ.1981.A monoclonal immunoglobulin G1in which some molecules possess glycosylated light chains–I.Site of glycosylation.Mol Immunol 18:793–805.

91.Middaugh CR,Litman GW.1987.Atypical glyco-

sylation of an IgG monoclonal cryoimmunoglobu-lin.J Biol Chem262:3671–3673.

JOURNAL OF PHARMACEUTICAL SCIENCES,VOL.97,NO.7,JULY2008DOI10.1002/jps 2440LIU ET AL.

Heterogeneity of Monoclonal Antibodies(15).doc 将本文的Word文档下载到电脑

精彩图片

热门精选

大家正在看

× 游客快捷下载通道(下载后可以自由复制和排版)

限时特价:7 元/份 原价:20元

支付方式:

开通VIP包月会员 特价:29元/月

注:下载文档有可能“只有目录或者内容不全”等情况,请下载之前注意辨别,如果您已付费且无法下载或内容有问题,请联系我们协助你处理。
微信:fanwen365 QQ:370150219