NIH-PA Author Manuscript

NIH-PA Author Manuscript

NIH-PA Author ManuscriptFigure 5. AP214 prevented hypotension and bradycardia by CLP

Telemetric recordings of mean arterial pressure (MAP) and heart rate (HR) after injection ofAP214 (closed circle) or vehicle (open circle) to normal CD-1 mice are shown in (A) and (B).Values are mean ± SEM (n = 5 in vehicle group, n = 5 in AP214 group). MAP and HR in CLPmice with AP214 treatment (closed circle) or vehicle injection (open circle), and sham-operatedgroup (open square) are shown in (C) and (D). Values are mean ± SEM (n = 3 in sham-operatedgroup, n = 5 in CLP group, n = 5 in AP214 group).