AP214 ameliorates sepsis-induced acute kidney injury and mor(12)
发布时间：2021-06-05
NIH-PA Author Manuscript
NIH-PA Author Manuscript
NIH-PA Author ManuscriptFigure 2. Effect of AP214 on AKI induced by CLP
Mice were sacrificed 18 hr after lethal CLP surgery for measurement of serum creatinine byHPLC method. AP214 was injected at 0, 6 hr (A, B) or only at 6 hr (delayed-treatment) (C).Equimolar native α-MSH (6.8 μg) was injected at 0 and 6 hr (B). Values are mean ± SEM (n= 4～5 in sham-operated group, n = 10～14 in CLP group, n = 7～10 in each AP214 treatmentgroup). #, P < 0.05 vs. CLP.
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