毫无疑问，三位科学家发展的碳—碳原子的偶联方法极大地促进了现代有机合成化学的发展，它不仅表现在对合成科学上的巨大贡献，而且这项技术已在全球的科研、医药开发与生产、发光材料和电子工业材料等领域得到广泛应用。不过我们也还必须看到这些方法的局限性，一个挑战性的问题是这些反应中均要使用卤代烃、硼酸酯及其衍生物等作为反应原料的一部分，但是这些原料绝大多数并不是自然界存在的或者容易人工合成的物质，另外在得到期望产物的同时，也还伴随有卤代物等盐类副产物的生成。

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