Product Data Sheet

Product Name:

CAS No.:

Cat. No.:

MWt:

Formula:

Purity :Niclosamide50-65-7HY-B0497327.12C13H8Cl2N2O4>98%

Solubility:DMSO <1 mg/mL; Water <1 mg/mL

Mechanisms:

Pathways:Anti-infection; Target:Antiparasitic

Biological Activity:

Niclosamide(BAY2353) is used for the treatment of most tapeworm infections by inhibiting DNA replication. Target: Antiparasitic

Niclosamide (< 5 μM) dose dependently inhibits STAT3-mediated luciferase reporter activity with IC50 of 0.25μM in HeLa cells. Niclosamide(< 2 μM) dose dependently inhibits the phosphorylation of STAT3 in Du145cells. Niclosamide (1 μM) inhibits the EGF-induced nuclear translocation of STAT3 in Du145 cells.

Niclosamide(< 2 μM) dose dependently inhibits the transcription of STAT3 downstream genes in Du145 cells.Niclosamide(< 10 μM) dose dependently induces G0/G1 arrest and apoptosis of Du145 cancer cells [1].Niclosamide(< 7.5 μM) promotes Frizzled1 endocytosis, downregulates Dishevelled-2 protein, and inhibitsWnt3A-stimulated beta-catenin stabilization and LEF/TCF reporter activity in U2OS cells [2]. Niclosamideinhibits the TNF-induced NF-...

References:

[1]. Ren, X., et al., Identification of niclosamide as a new small-molecule inhibitor of the STAT3 signalingpathway. ACS Medicinal Chemistry Letters, 2010. 1(9): p. 454-459.

[2]. Chen, M., et al., The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling. Biochemistry, 2009.48(43): p. 10267-74.

[3]. Jin, Y., et al., Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells:

inactivation of the NF-kappaB pathway and generation of reactive oxygen species. Cancer Res, 2010. 70(6):p. 2516-27.

Caution: Not fully tested. For research purposes only

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