巴西苏木素作用机制 - Medchemexpress - MCE中国

Brazilin Cat. No.:

HY-N0072CAS No.:

474-07-7分⼦式:

C₁₆H₁₄O₅分⼦量:

286.28作⽤靶点:

Apoptosis; Autophagy 作⽤通路:

Apoptosis; Autophagy 储存⽅式:Powder

-20°C 3 years 4°C 2 years In solvent -80°C

6 months -20°C 1 month BIOLOGICAL ACTIVITY

⽣物活性Brazilin 是⼀种来⾃⼏种热带硬⽊的⼼材的红⾊染料前体。Brazilin 抑制细胞增殖，促进细胞凋亡并通过 AMPK/mTOR

途径诱导⾃噬。Brazilin 显⽰出软⾻保护和抗炎活性[1][2][3]。

REFERENCES

[1]. Dapson RW, et al. Brazilwood, sappanwood, brazilin and the red dye brazilein: from textile dyeing and folk medicine to biological staining and musical instruments. Biotech Histochem. 2015;90(6):401-23.

[2]. Jia Y, et al. [Effect of brazilin on apoptosis and autophagy of tongue cancer Tca8113 cells and its molecular mechanism]. Nan Fang Yi Ke Da Xue Xue Bao. 2019 Mar 30;39(3):351-356.

[3]. Weinmann D, et al, Brazilin blocks catabolic processes in human osteoarthritic chondrocytes via inhibition of NFKB1/p50. J Orthop Res. 2018 Sep;36(9):2431-2438.

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Caution: Product has not been fully validated for medical applications. For research use only.

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Product Data Sheet

Inhibitors •Agonists •Screening Libraries

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