Product DatasheetTissue specificity

Involvement in diseaseWidely expressed, but most abundant in macrophages.Defects in ABCA1 are a cause of high density lipoprotein deficiency type 1 (HDLD1) [MIM:205400]; also known

as analphalipoproteinemia or Tangier disease (TGD). HDLD1 is a recessive disorder characterized by absence of

high density lipoprotein (HDL) cholesterol from plasma, accumulation of cholesteryl esters, premature coronary

artery disease (CAD), hepatosplenomegaly, recurrent peripheral neuropathy and progressive muscle wasting and

weakness.

Defects in ABCA1 are a cause of high density lipoprotein deficiency type 2 (HDLD2) [MIM:604091]; also known

as familial hypoalphalipoproteinemia (FHA). HDLD2 is inherited as autosomal dominant trait. It is characterized

by moderately low HDL cholesterol, predilection toward premature coronary artery disease (CAD) and a reduction

in cellular cholesterol efflux.

Belongs to the ABC transporter superfamily. ABCA family.

Contains 2 ABC transporter domains.

Multifunctional polypeptide with two homologous halves, each containing an hydrophobic membrane-anchoring

domain and an ATP binding cassette (ABC) domain.

Phosphorylation on Ser-2054 regulates phospholipid efflux.

Palmitoylation by DHHC8 is essential for membrane localization.

Membrane.Sequence similaritiesDomainPost-translationalmodificationsCellular localization

Target information above from: UniProt accession O95477 The UniProt Consortium

The Universal Protein Resource (UniProt) in 2010

Nucleic Acids Res. 38:D142-D148 (2010) .

Database linksEntrez Gene: 373945 Chicken

Entrez Gene: 11303 Mouse

Entrez Gene: 313210 Rat

Entrez Gene: 716107 Rhesus monkey

SwissProt: P41233 Mouse

Unigene: 277376 Mouse

Unigene: 148916 Rat

ABC 1 antibody

ABC Transporter 1 antibody

ABC-1 antibody

ABC1 antibody

ABCA 1 antibody

ABCA1 antibody

ABCA1_HUMAN antibody

ATP binding Cassette 1 antibody

ATP binding cassette sub family A ABC1 member 1 antibody

ATP binding cassette sub family A member 1 antibody

ATP binding Cassette Transporter 1 antibody

ATP-binding cassette 1 antibody

ATP-binding cassette sub-family A member 1 antibody

ATP-binding cassette transporter 1 antibody

CERP antibody

Cholesterol efflux regulatory protein antibody

FLJ14958 antibody

HDLDT1 antibody

Membrane bound antibody

MGC164864 antibody

MGC165011 antibody

TD antibody

TGD antibodyAlternative names

Anti-ABCA1 antibody images