中国科学: 化学 2014年 第44卷 第5期

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Mass spectrometry-based metabolomics and their developments in China

WANG Xian1, 2, LIN ShuHai2, CAI ZongWei2*

1 College of Chemistry and Materials Science, South-Central University for Nationalities, Wuhan 430074, China 2 State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Kowloon, China *Corresponding author (email: zwcai@hkbu.edu.hk)

Abstract: As an important component of systems biology, metabonomics (or metabolomics) is a science of studying metabolites and the corresponding changes in living systems. Mass spectrometry is one of the primary analytical tools of metabolomic studies and has been widely applied in many research areas. This paper overviews the recent developments in technologies and applications of mass spectrometry-based metabolomics, highlights major progress and achievement that have been recently gained in China in this field, and discusses the existing problems of mass spectrometry-based metabolomics and the future perspectives.

Keywords: metabonomics, mass spectrometry, systems biology

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